Antiviral Colloidal Silver Composition (US Patent)

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Proc Nat! Acad Sci 1981;78:7180-7184. Tallman JF. Paul SM. Gallager DW: Receptors for the age of anxiety: Pharmacology of the benzodiazepines. Science 1980;207 ;274-281. Thiebot M-H. Soubrie P: Behavioural pharmacology of the benzodiazepines. in Costa E. (ed): Benzodiazepines - Molecular Biology to Clinical Practice. New York. Raven Press. 1983. Woods JH: Benzodiazepine dependence studies in animals: An overview. Drug Dev Res Supp 1982;1:77-81. Yanagita T: Dependence-producing effects of anxiolytics, in Hoffmeister F, Stille G (eds): Handbook of Experimental Pharmacology.

Mohler H, Battersby MK, Richards JG: Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label. Proc Natl Acad Sci 1980;77: 1666-1670. Mohler H, Burkard WP, Keller HH, el at: Benzodiazepine antagonist Ro 15-1788: Binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cAMP levels. I Neurochem 1981;37:714-722. Mohler H, Okada T: Benzodiazepine receptors: Demonstration system. Science 1977;198:849-851. III the central nervous Mohler H, Richards JG: Agonist and antagonist benzodiazepine receptor interaction in vitro.

In pharmacokinetic terms, benzodiazepine action may be terminated if the drug disappears from its receptor site, which can happen by one of two mechanisms. The first mechanism is by drug distribution, in which the drug egresses from its site of action in the brain and is taken up into peripheral storage sites, principally in adipose tissues. The second pharmacodynamic mechanism is biotransformation or clearance - the drug disappears from the receptor site as it is irreversibly biotransformed by the Jiver.

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