Antioxidants and Cardiovascular Disease by Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa,

By Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)

Antioxidants and heart problems, moment variation addresses a fancy yet very well timed and interesting challenge in cardiovascular medication. it's written through well-known specialists within the fields of atherosclerosis and antioxidants. it may be of curiosity not just to academicians but additionally to practising physicians. the 1st 5 chapters evaluation the overall techniques of oxidative tension and their dating to lipid metabolism, endothelial disorder, genetics and transcriptional components. the subsequent seven chapters describe lately outlined markers of oxidative rigidity, pharmacological compounds with antioxidant task, normal antioxidants present in micronutrients and in nutrient-rich diets, and reports the new proof for his or her efficacy or loss of efficacy in sufferers with heart problems or cardiovascular danger components. The final seven chapters speak about the aptitude healing advantages of antioxidants in a few cardiovascular stipulations which come with atherosclerosis, restenosis after percutaneous coronary intervention, significant cardiovascular hazard components equivalent to high blood pressure, diabetes mellitus and dyslipidemia, and left ventricular disorder and congestive center failure.

Martial G. Bourassa, M.D. and Jean-Claude Tardif, M.D. are affiliated with the Montreal center Institute, study heart and division of drugs, school of medication, college of Montreal, Montreal, Quebec, Canada.

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Harats D, Shaish A, George J et al. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vase Biol 2000;20:2100-5. 38 S. Tsimikas 45. Reilly KB, Srinivasan S, Hatley ME et al. 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo. J Biol Chem 2004;279:9440-50. Shih DM, Xia YR, Wang XP et al. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.

Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? Proc Natl Acad Sci U S A 1993;90:5929-33. Babior BM. Phagocytes and oxidative stress. Am J Med 2000;109:33-44. Cyrus T, Witztum JL, Rader DJ et al. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J Clin Invest 1999;103:1597-604. Cyrus T, Pratico D, Zhao L et al. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice.

E. increased OxPL/apoB ratio), in parallel with strikingly similar increases in Lp(a), suggesting binding by Lp(a). e. marked reduction in total apoB-OxPL but increased in OxPL/apoB in the remaining apoB particles at steady state) in conjunction with significantly reduced OxPL epitopes in the vessel wall. These data support the hypothesis that statins or aggressive lipid lowering promote mobilization and clearance of pro-inflammatory OxPL from the vessel wall and circulation, respectively, which may contribute to a rapid reduction in ischemic events.

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