Age-Related Macular Degeneration by Jennifer I. Lim

By Jennifer I. Lim

This reference showcases exudative and nonexudative AMD remedy innovations utilizing argon and diode lasers, submacular and macular translocation surgical procedure, photodynamic remedy, radiation, feeder vessel remedy, thermotherapy, and antiangiogenesis medications. together with one hundred sixty colour illustrations, Age-Related Macular Degeneration will profit medical ophthalmologists, pathologists, physiologists, and pharmacologists; optometrists; telephone and molecular biologists and biochemists; retinal experts; AMD researchers; and graduate and clinical college scholars in those disciplines.

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Invest Ophthalmol Vis Sci 1986;27:145–152. 70. Feeney-Burns L, Hilderbrande ES, Eldridge S. Aging human RPE: morphometric analysis of macular, equatorial and peripheral cells. Invest Ophthalmol Vis Sci 1984;25:195–200. 71. Schmidt SY, Peisch RD. Melanin concentration in normal human retinal pigment epithelium. Regional variation and age-related reduction. Invest Ophthalmol Vis Sci 1986;27:1063–1067. 72. Eldred GE. Lipofuscin and other lyosomal storage deposits in the retinal pigment epithelium.

BlinD are composed of granular, vesicular, or membranous material, with foci of wide-spaced collagen. The origin of that membranous debris is thought to be membranes of photoreceptor outer segments, delivered by the RPE in the form of vacuoles and vesicles (6,7,9). Soft drusen (large, poorly delineated drusen) may represent focal accentuation of that basal linear material, while its diffuse deposition forms BlinD (3,8). Soft drusen are seen by light microscopy as localized deposition of granular, pale material with sloping edges (4).

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 1999;40:737–743. 81. Sparrow JR, Parrish CA, Hashimoto M, Nakanishi K. A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci 1999;40:2988–2995. 82. Rawes V, Kipling D, Kill IR, Faragher RG. The kinetics of senescence in retinal pigmented epithelial cells: a test for the telomere hypothesis of ageing? Biochemistry (Mosc) 1997;62:1291–1295.

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