2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD

By Ramana S. Moorthy, MD

A dialogue of the medical method of uveitis results in commonly rewritten chapters on noninfectious (autoimmune) and infectious varieties of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and problems of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.

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Extra resources for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

Example text

The presence ofT lymphocytes or B lymphocytes within the normal posterior segment has not been carefully addressed, but effector cells appear to be absent from the normal retina. The density of mast cells is moderate in the choroid, especially around the arterioles, but lymphocytes are present only in very low density. Eosinophils and neutrophils appear to be absent. Under various clinical or experimental conditions, however, high densities of T lymphocytes, B lymphocytes, macrophages, and neutrophils can infiltrate the choroid, choriocapillaris, and retina.

The regulation determining whether a Th 1 or a Th2 response develops consequent to exposure to a particular antigen is not entirely understood, but presumed variables include cytokines preexisting in the microenvironment, the nature of the antigen, the amount of antigen, and the type of APC. For example, IL-12, which is produced by macrophage APCs, might preferentially induce Th 1 responses. von Andrien UH, Mackay CR. T-cell function and migration-two N EnglJ Med. 2000;343:1020-1034. sides of the same coin.

This gene becomes expressed in any cell infected by the virus. Immune clearance of the virus has been shown to cause loss of expression of the transferred gene in other body sites. If immune privilege protects the viral vector or the protein synthesized by the transferred gene from immune clearance, then subretinal gene therapy might enjoy greater success in the eye than elsewhere. This topic is currently under intense investigation. 41 CHAPTER 4 Mechanisms of Immune Effector Reactivity Immunologists have long been fascinated with all 3 phases of the adaptive immune response, as well as related issues such as developmental biology and the ontogeny oflymphoid precursors.

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